A patient undergoing a skin examination and treatment consultation in classical dermatology. A specialist in skin health and skin diseases examines and explains the female patient's skin in the bright rooms of the Frankfurt dermatology practice.

Early detection of HPV-related carcinomas - Prevo-Check®

Prevo-Check® - Early detection of HPV-related carcinomas

Human papillomaviruses (HPV) can, in rare cases, cause cancers of the mouth and throat, as well as in the anogenital area. HPV is widespread, and approximately 80% of all sexually active people come into contact with the virus at least once in their lives. In rare cases, the virus actively interferes with the life of the affected skin cells, resulting in changes known as precancerous lesions. These cells can then begin to multiply uncontrollably and develop into tumors if this is not detected in time.

An HPV vaccination protects against infection with cancer-causing HPV. Vaccination should be carried out before a possible HPV infection. The Standing Committee on Vaccination (STIKO) therefore recommends vaccination between the ages of 9 and 14, but no later than the 18th birthday.

In addition to our thorough skin cancer screening, we use the Prevo-Check® test, a new method for the early detection of HPV-induced cancer, which very reliably detects antibodies against HPV in the blood. This test allows for the earlier detection of precancerous lesions. These can then usually be treated more successfully with gentler therapies than advanced tumors.

How does the examination proceed?

We use the Prevo-Check® rapid test for this purpose. A drop of blood is taken, for example, from the fingertip, and your result is available after only 20 minutes. If the test result is negative, no further action is required. We recommend repeating the test annually. If the test result is positive, meaning that antibodies have been detected in the blood, a comprehensive diagnostic workup should be performed. Since the antibodies circulate freely in the blood, the test does not provide any information about the location of the infection. In the case of a positive test result, a targeted, interdisciplinary examination for suspicious lesions is recommended.

Who should get tested?

A Prevo-Check® test is recommended for all patients from the age of 40. The rapid test is particularly recommended for...

High-risk patients who are particularly likely to develop HPV-related tumors due to their lifestyle or pre-existing conditions. Risk factors include:

  1. High tobacco consumption (smoking, snuff or chewing tobacco)
  2. Regular alcohol consumption
  3. Ongoing HPV16 infections in oneself or one's partner
  4. Patients who have a history of HPV-related tumors
  5. Patients with condylomas
  6. Immunodeficiency or
  7. Immunosuppression
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